Week 1 of the NFL season is in the books, and if history tells us anything, it’s that overreactions run wild after opening weekend. The sharp approach for bettors is to identify value without getting swept up in the noise. Below, we’ll break down some of the best NFL bets for Week 2, including spreads, totals and even player props like anytime TD bets.
Week 2 NFL Best Bets, Anytime TDs and Player Props
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Commanders vs. Packers (Thursday Night Football)
The Packers dominated the Lions in Week 1, but it’s worth asking whether Detroit’s offseason coordinator changes and offensive line injuries played a role in that lopsided loss. Washington, meanwhile, rolled past the Giants in convincing fashion.
At +3.5, the Commanders offer strong value. Jayden Daniels’ mobility helps sustain drives, and this game profiles as a grind-it-out primetime matchup.
Best Bet: Commanders +3.5
Giants vs. Cowboys
Dak Prescott and the Cowboys fell just short against Philadelphia, while the Giants offense sputtered against Washington. New York’s lack of reliable playmakers beyond Malik Nabers is glaring.
Inside a 6-point spread, Dallas looks like the safer side.
Best Bet: Cowboys -5.5
Bills vs. Jets
Buffalo escaped Baltimore with a dramatic win, but divisional games against the Jets are rarely straightforward. New York nearly stole one against Pittsburgh, with Justin Fields showing flashes, Breece Hall back to pre-injury form and Garrett Wilson looking unstoppable.
At +6.5, the Jets as home underdogs are too good to pass up. Don’t be shocked if they win outright.
Best Bet: Jets +6.5
49ers vs. Saints
San Francisco is banged up. George Kittle, Brandon Aiyuk and Brock Purdy are all questionable. The Saints aren’t a powerhouse, but in a home underdog role, they’re worth consideration.
If Purdy sits, Saints +4.5 becomes the clear play. If he starts, expect this line to move toward the 49ers.
Lean: Saints +4.5
Seahawks vs. Steelers
The Steelers stole a win in Week 1, but injuries on defense and Mike Tomlin’s shaky record as a home favorite loom large. Seattle desperately needs to avoid an 0–2 start.
Best Bet: Seahawks +3
Rams vs. Titans
The Rams offense funneled almost all production to Puka Nacua and Davante Adams, but this matchup tilts toward Tennessee’s defense. Rookie Cam Ward struggled in Denver, and now he faces another physical defense.
Best Bet: Titans +5.5
Browns vs. Ravens
Divisional underdogs catching double digits always deserve a look. Joe Flacco showed flashes last week despite late turnovers, and Cleveland’s defense harassed Joe Burrow all afternoon.
Best Bet: Browns +11.5
Jaguars vs. Bengals
Jacksonville impressed under new head coach Liam Coen, while Cincinnati barely survived Cleveland. Until the Bengals prove their defense can stop anyone, getting more than a field goal on the Jags is appealing.
Best Bet: Jaguars +3.5
Lions vs. Bears
Detroit’s offense never found a rhythm in Week 1, and coaching decisions raised eyebrows. Still, the Bears’ late collapse against Minnesota doesn’t inspire confidence either.
With questions in Chicago’s secondary, the lean is toward Detroit inside the dome.
Lean: Lions -5.5
Patriots vs. Dolphins
Miami’s disastrous Week 1 loss to Indianapolis has public sentiment at rock bottom, which makes this a contrarian buy-low spot. Add in real home-field advantage from the Miami heat, and the Dolphins are live here.
Best Bet: Dolphins -1.5
Panthers vs. Cardinals
Ugly game, but inflated line. The Panthers were humiliated in Week 1, and historically, big underdogs off a blowout loss can bounce back.
Lean: Panthers +6.5
Colts vs. Broncos
The Colts are home dogs despite looking like a competent, balanced football team. Denver’s offense remains inconsistent, and last week’s win was more survival than dominance.
Best Bet: Colts +2.5
Eagles vs. Chiefs
A potential Super Bowl preview. The Eagles are slight road favorites, but with injury concerns and Kansas City’s travel schedule, this one is tricky.
Best angle might be a Chiefs teaser piece (+7.5).
Lean: Eagles -0.5.
Falcons vs. Vikings
The Vikings showed grit in a comeback win, but the Falcons had every chance in Week 1 before special teams doomed them. Injuries to Drake London and Darnell Mooney are key; monitor before betting.
Lean: Falcons +5
Buccaneers vs. Texans
Tampa Bay’s offensive line is in shambles, while Houston’s defense looks ready to carry them all season. With home-field edge, the Texans -2.5 is one of the sharper Week 2 bets.
Best Bet: Colts +2.5
Top NFL Player Props & Anytime TD Bets for Week 2
Alongside spreads and totals, Week 2 offers juicy player props:
- Garrett Wilson Anytime TD – The Jets’ WR1 is unstoppable and should see heavy volume vs. Buffalo.
- Breece Hall Over 54.5 Rushing Yards – Looked explosive in Week 1; now faces a Bills defense vulnerable on the ground.
- Christian McCaffrey Anytime TD – If he’s healthy, he remains San Francisco’s offensive engine.
Final Thoughts
NFL Week 2 is about balancing reaction with restraint. Overreactions to Week 1 are everywhere, but value lives in contrarian spots: Home underdogs, inflated lines and injury-based market swings.
