OddsShopper’s Expert NFL AI walks you through the best betting odds, trends, and predictions for the Arizona Cardinals’s matchup versus the San Francisco 49ers.
The San Francisco 49ers will be the visiting team versus the Arizona Cardinals, with kickoff at 11/21/2022 8:15 PM ET.
San Francisco 49ers vs. Arizona Cardinals Betting Odds
| Team | Moneyline | Spread | O/U |
|---|---|---|---|
| Arizona Cardinals | +380 | +10.0, -110 | Over 43.0, -110 |
| San Francisco 49ers | -475 | -10.0, -110 | Under 43.0, -110 |
The San Francisco 49ers are favored in this matchup with -475 odds for the moneyline and -110 odds for the -10.0 spread on DraftKings.
The Arizona Cardinals are +10.0 point underdogs, with -110 odds and +380 odds for the moneyline in this matchup vs the San Francisco 49ers.
Moneyline Odds
| Bet Side | BetMGM | Caesars | DraftKings | FanDuel | PointsBet | Unibet | WynnBET |
|---|---|---|---|---|---|---|---|
| Arizona Cardinals | +310 | +360 | +380 | +350 | +350 | +360 | +360 |
| San Francisco 49ers | -400 | -480 | -475 | -450 | -450 | -435 | -475 |
Moneyline trends
- In the last 1 of 2 games, the San Francisco 49ers have not covered the Moneyline bet (ROI: -9.7%)
Point Spread Odds
| Bet Side | BetMGM | Caesars | DraftKings | FanDuel | PointsBet | Unibet | WynnBET |
|---|---|---|---|---|---|---|---|
| Arizona Cardinals | +10.0, -110 | +10.0, -110 | +10.0, -110 | +9.5, -106 | +10.0, -107 | +10.0, -110 | +10.0, -110 |
| San Francisco 49ers | -10.0, -110 | -10.0, -110 | -10.0, -110 | -9.5, -114 | -10.0, -107 | -10.0, -110 | -10.0, -110 |
Point Spread trends
- In the last 2 of 2 Away games, the San Francisco 49ers have not covered the Point Spread bet (ROI: -100.0%)
- In the last 2 of 3 games, the San Francisco 49ers have not covered the Point Spread bet (ROI: -36.1%)
- The Arizona Cardinals have not hit the Point Spread in 1 of their last 2 games (ROI: -4.5%)
Total Odds
| Bet Side | BetMGM | Caesars | DraftKings | FanDuel | PointsBet | Unibet | WynnBET |
|---|---|---|---|---|---|---|---|
| Over | 43.0, -110 | 43.0, -110 | 43.0, -110 | 43.5, -110 | 43.0, -107 | 43.5, -109 | 43.5, -110 |
| Under | 43.0, -110 | 43.0, -110 | 43.0, -110 | 43.5, -110 | 43.0, -107 | 43.5, -112 | 43.5, -110 |
Our OddsShopper AI Model Pick Recommendation:
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Our Favorite Player Props for the San Francisco 49ers vs. Arizona Cardinals Matchup
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Player Prop Trends
- In the last 1 of 2 games, Jimmy Garoppolo has not covered the Interceptions Thrown Under bet (ROI: -9.0%)
- Jimmy Garoppolo has covered the Total Pass Completions Under in 2 of his last 2 games (ROI: 84.8%)
- Jimmy Garoppolo has not covered the Total Passing + Rushing Yards Over in 1 of his last 2 games (ROI: -6.5%)
- Jimmy Garoppolo has hit the Total Passing Attempts Under in 2 of his last 2 games (ROI: 88.5%)
- In the last 2 of 2 games, Jimmy Garoppolo has hit the Total Passing Touchdowns Under bet (ROI: 66.8%)
Looking for an edge on this NFL matchup featuring the San Francisco 49ers vs Arizona Cardinals?
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